Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Proprietary BlendBoswellia (Indian Frankincense) (gum) extract, Bromelain (600 GDU/g), Ginger (root) extract, White Willow (bark) (Salix alba) extract, Cayenne (fruit) powder
800 mg
**
Hyaluronic Acid (as Sodium Hyaluronate)
100 mg
**
Top Medical Research Studies
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
9
We explored a creative approach to treat rheumatoid arthritis, focusing on a new delivery method for tacrolimus using hyaluronic acid-coated nanogels.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
7.5
Instant effects
1 people found this helpful
I believe this is the best Bud available. I've tried many others, but this one showed immediate effects. It's essential to remember to consume at least 2 litres of water daily.
Read More
7.5
Consistent quality
I adore this company's supplements for their excellent quality. They provide a suitable dosage for supporting joint and skin health. I take them alongside chondroitin, vitamin C, and MSM, and I am consistently pleased with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
- All Researches
9.5
We explored a novel injectable hydrogel designed to treat rheumatoid arthritis, which often causes joint lubrication issues and cartilage damage. This hydrogel incorporates modified hyaluronic acid and nanozymes that work together to reduce inflammation and promote cartilage repair.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
Read More
9
We aimed to tackle the side effects of long-term use of tofacitinib, a well-known treatment for rheumatoid arthritis. By creating hyaluronic-acid-coated transethosomes, we delivered tofacitinib directly to affected areas, enhancing efficacy while reducing side effects. Our results showed significant anti-inflammatory effects, with marked reductions in inflammatory markers in treated rats compared to conventional delivery methods. This suggests that our targeted approach may offer a promising alternative for managing rheumatoid arthritis with fewer systemic impacts.
Read More
9
Innovative dual-drug treatment examined
We explored the potential of hyalurosomes that combine dexamethasone and luteolin as a treatment for rheumatoid arthritis. In a study using a rat model, we observed significant reductions in inflammatory markers like TNF-α and MDA, suggesting these dual drug-loaded hyalurosomes could effectively decrease inflammation and swelling in joints.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Read More
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Instant effects
1 people found this helpful
I believe this is the best Bud available. I've tried many others, but this one showed immediate effects. It's essential to remember to consume at least 2 litres of water daily.
Read More
7.5
Consistent quality
I adore this company's supplements for their excellent quality. They provide a suitable dosage for supporting joint and skin health. I take them alongside chondroitin, vitamin C, and MSM, and I am consistently pleased with the results.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. doi:10.1038/s41467-025-58059-z
- Tang W, Huang X, Yi YD, Cao F, Deng M, et al. Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway. J Nanobiotechnology. 2025;23:89. doi:10.1186/s12951-024-03082-3
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. doi:10.1016/j.colsurfb.2025.114497
- Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073
- Liu X, Chen X, Fei Y, Zhang J, Yue O, et al. Locally Injectable, ROS-Scavenging, and ROS-/pH-Responsive Polymeric-Micelles-Embedded Hydrogels for Precise Minimally Invasive and Long-Lasting Rheumatoid Therapy. Adv Healthc Mater. 2025;14:e2403579. doi:10.1002/adhm.202403579
- Papp FR, Katko M, Csiki R, Galgoczi E, Molnar Z, et al. Characteristics of Hyaluronan Metabolism During Myofibroblast Differentiation in Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2024;65:13. doi:10.1167/iovs.65.13.13
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiOâ‚‚ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. doi:10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. doi:10.1186/s12951-024-02784-y
- Xu M, Fu T, Zhang C, An Z, Yan J, et al. Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy. J Control Release. 2024;375:60. doi:10.1016/j.jconrel.2024.08.046
- Deng YS, Shen XY, Long MT, Zheng H, Li B, et al. [MMPs/pH synergically responsive XTS-Prussian blue nanoparticles inhibiting proliferation and migration of RAFLS assisted with laser irradiation]. Zhongguo Zhong Yao Za Zhi. 2024;49:2906. doi:10.19540/j.cnki.cjcmm.20240304.303
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. doi:10.1016/j.ijpharm.2024.124449
- Liu X, Zhang Q, Cao Y, Hussain Z, Xu M, et al. An Injectable Hydrogel Composing Anti-Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis. Adv Healthc Mater. 2024;13:e2304668. doi:10.1002/adhm.202304668
- Zhu H, Huang D, Wang J, Zhao Y, Sun L. Viral Mimicking Polyplexes as Hierarchical Unpacking Vectors for Rheumatoid Arthritis Treatment. Adv Sci (Weinh). 2024;11:e2402888. doi:10.1002/advs.202402888
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. doi:10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. doi:10.1021/acs.biomac.4c00556
